PXD033901-1

PXD033901 is an original dataset announced via ProteomeXchange.

Title	Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan
Description	Despite longstanding scientific interest in the centrality of mitochondria to biological aging, directly controlling mitochondrial function to test causality has eluded researchers. We show that specifically boosting mitochondrial membrane potential through a light-activated proton pump reversed age-associated phenotypes and extended C. elegans lifespan. We show that harnessing the energy of light to experimentally increase mitochondrial membrane potential during adulthood alone is sufficient to slow the rate of aging.
HostingRepository	PRIDE
AnnounceDate	2022-11-11
AnnouncementXML	Submission_2022-11-10_23:58:57.396.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	ChristinaLudwig
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-16 06:46:44	ID requested
⏵ 1	2022-11-10 23:58:57	announced

Dataset with its publication pending

submitter keyword: C. elegans,aging

ChristinaLudwig
contact affiliation	Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University Munich (TUM), Freising, 85353, Germany
contact email	tina.ludwig@tum.de
lab head
ChristinaLudwig
contact affiliation	TU Munich
contact email	tina.ludwig@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD033901

PRIDE project URI

• PRIDE
  1. PXD033901
     1. Label: PRIDE project
     2. Name: Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan