PXD033863-1

PXD033863 is an original dataset announced via ProteomeXchange.

Title	Sox9 directs divergent epigenomic states in brain tumor subtypes
Description	Epigenetic dysregulation is a universal feature of cancer that results in altered patterns of gene expression that drive malignancy. Brain tumors exhibit subtype-specific epigenetic alterations, however the molecular mechanisms responsible for these diverse epigenetic states remain unclear. Here we show that the developmental transcription factor Sox9 differentially regulates epigenomic states in high-grade glioma (HGG) and ependymoma (EPN). These contrasting roles for Sox9 correspond with protein interactions with histone deacetylating complexes in HGG, and association with the Rela oncofusion in EPN. Together, our studies demonstrate how epigenomic states are differentially regulated in distinct subtypes of brain tumors, while revealing divergent roles for Sox9 in HGG and EPN tumorigenesis.
HostingRepository	PRIDE
AnnounceDate	2022-07-13
AnnouncementXML	Submission_2022-07-12_23:22:15.609.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antrix Jain
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-12 09:29:28	ID requested
⏵ 1	2022-07-12 23:22:15	announced

Dataset with its publication pending

submitter keyword: high grade glioma, ependymoma, epigenetics, histone, transcription

Benjamin Deneen
contact affiliation	Center for Cell and Gene Therapy Department of Neurosurgery Baylor College of Medicine Houston, Texas, USA
contact email	deneen@bcm.edu
lab head
Antrix Jain
contact affiliation	Baylor College of Medicine
contact email	antrixj@bcm.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/07/PXD033863

PRIDE project URI

• PRIDE
  1. PXD033863
     1. Label: PRIDE project
     2. Name: Sox9 directs divergent epigenomic states in brain tumor subtypes