PXD033845-2

PXD033845 is an original dataset announced via ProteomeXchange.

Title	Insulin receptor signaling in pancreatic acinar cells contributes to KrasG12D-driven cancer initiation in the context of diet-induced obesity
Description	Phosphoproteomic analysis to elucidate whether high-fat diet induced hyperinsulinemia contributes to pancreatic cancer directly through insulin receptor (INSR) signaling in KrasG12D-expressing pancreatic acinar cells.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:12:28.318.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vincent Richard
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-12 04:30:46	ID requested
1	2023-10-19 07:44:45	announced
⏵ 2	2023-11-14 07:12:28	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:06:35	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: insulin resistance, PanIN, obesity, hyperinsulinemia,pancreatic ductal adenocarcinoma

Christoph H Borchers
contact affiliation	1¬ MRM Proteomics Inc, Montreal, Quebec, Canada 2 Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada 3 Gerald Bronfman Department of Oncology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
contact email	christoph.borchers@mcgill.ca
lab head
Vincent Richard
contact affiliation	Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University
contact email	vincentroyrichard@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD033845

PRIDE project URI

• PRIDE
  1. PXD033845
     1. Label: PRIDE project
     2. Name: Insulin receptor signaling in pancreatic acinar cells contributes to KrasG12D-driven cancer initiation in the context of diet-induced obesity