PXD033794-2

PXD033794 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues
Description	To explore the biological insights into squamous cell carcinoma (SCC) derived from different organs, we reported a deep proteomic analysis of 333 SCCs of 17 organs and 69 adenocarcinomas (ACs) of 7 organs. Proteomic comparison between pan-SCCs and pan-ACs identifies distinguishable pivotal pathways, including keratinization, glucose metabolism, and extracellular matrix. Molecules in those pathways play consistent adverse or opposite prognostic roles in ACs and SCCs. A comparison between common and rare SCCs highlights lipid metabolism may reinforce the malignancy of rare SCCs. Proteomic clusters reveal anatomical features, and kinase-transcription factor networks indicate differential SCC initiation, while immune subtyping reveals diverse tumor microenvironments across and within diagnoses and identified potential druggable targets. HPV16 infected anogenital SCCs exhibit immune escape and higher inositol phosphate catabolic process. Furthermore, tumor-specific proteins provide candidates with differentially diagnostic values. This proteomics architecture represents a unique public resource for researchers seeking a better understanding of SCCs.
HostingRepository	iProX
AnnounceDate	2022-05-19
AnnouncementXML	Submission_2023-02-20_19:18:14.878.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qi Song
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-10 19:37:19	ID requested
1	2022-05-21 23:38:19	announced
⏵ 2	2023-02-20 19:18:15	announced	2023-02-21: Update information.

Song Q, Yang Y, Jiang D, Qin Z, Xu C, Wang H, Huang J, Chen L, Luo R, Zhang X, Huang Y, Xu L, Yu Z, Tan S, Deng M, Xue R, Qie J, Li K, Yin Y, Yue X, Sun X, Su J, He F, Ding C, Hou Y, Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues. Nat Commun, 13(1):4167(2022) [pubmed]

submitter keyword: Squamous cell carcinoma, Adenocarcinoma, Proteome

Yingyong Hou
contact affiliation	Department of Pathology, Zhongshan Hospital, Fudan University
contact email	hou.yingyong@zs-hospital.sh.cn
lab head
Qi Song
contact affiliation	Human Phenome Institute, Fudan University
contact email	qisong@fudan.edu.cn
dataset submitter

iProX dataset URI