PXD033744-1

PXD033744 is an original dataset announced via ProteomeXchange.

Title	Serum APOC1 levels are decreased in seroconverted children who progress to type 1 diabetes at a young age
Description	Biomarkers are needed to accurately predict and monitor type 1 diabetes progression during the substantially heterogeneous presymptomatic period of the disease development. To address this concern, we studied temporal changes in the plasma and serum proteomes of < 5-year-old children with HLA-conferred risk for type 1 diabetes by analysing longitudinal sample series that were collected at regular intervals between birth and diagnosis. Using mass spectrometry-based discovery proteomics, longitudinal plasma sample series from multiple autoantibody positive children who had rapidly progressed to type 1 diabetes before 4 years of age were analysed and compared with similar measurements from age and gender matched children who were either single autoantibody positive or autoantibody negative. Following analysis of the data with an additive Gaussian process regression model (LonGP), targeted proteomics was used to verify 11 biomarker candidates in a larger independent yet similar cohort of children with more frequent sampling points. The data reiterated extensive age related trends for protein levels in young children. Further, by combining the utility of LonGP together with the targeted analysis in an extended cohort, these analyses demonstrated that the serum levels of two peptides unique for apolipoprotein C1 (APOC1) were decreased after the appearance of the first autoantibody and remained relatively less abundant in children who progressed to type 1 diabetes in comparison to autoantibody negative children.
HostingRepository	PRIDE
AnnounceDate	2023-09-26
AnnouncementXML	Submission_2023-09-26_07:24:05.021.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maria KaroliinaHirvonen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-06 06:57:58	ID requested
⏵ 1	2023-09-26 07:24:05	announced
2	2023-11-14 09:05:30	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:04:00	announced	2024-10-22: Updated project metadata.

Hirvonen MK, Lietz, é, n N, Moulder R, Bhosale SD, Koskenniemi J, V, ä, h, ä, -M, ä, kil, ä M, Nurmio M, Ore, š, i, č M, Ilonen J, Toppari J, Veijola R, Hy, ö, ty H, L, ä, hdesm, ä, ki H, Knip M, Cheng L, Lahesmaa R, Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes. Sci Rep, 13(1):15941(2023) [pubmed]

submitter keyword: Human, plasma, serum, type 1 diabetes, LC-MS/MS

RiittaLahesmaa
contact affiliation	Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
contact email	riitta.lahesmaa@utu.fi
lab head
Maria KaroliinaHirvonen
contact affiliation	Turku Bioscience Centre, University of Turku and Åbo Akademi University
contact email	karoliina.hirvonen@utu.fi
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD033744
     1. Label: PRIDE project
     2. Name: Serum APOC1 levels are decreased in seroconverted children who progress to type 1 diabetes at a young age