PXD033734 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of affinity-purified praja2 complexes |
| Description | Praja2 is a RING E3 ubiquitin ligase, widely expressed in mammalian cells and tissues which is involved in essential aspects of cell physiology. Several signaling pathways are regulated by praja2. The stability of regulatory PKA subunits is directly regulated by Praja2, which binds and tethers cAMP-dependent protein kinase (PKA) to intracellular membranes and organelles, ensuring efficient integration, propagation and amplification of the locally-generated cAMP to distinct target compartments. By regulating cAMP signaling, praja2 efficiently couples phosphorylation to ubiquitination of protein kinases, scaffolds and effectors, with important implication for neuronal activity, development, inflammatory responses, ciliogenesis, cell growth and metabolism. Dysregulation of praja2-regulated signaling pathways has been causally linked to the growth and progression of glioblastoma. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-25 |
| AnnouncementXML | Submission_2026-06-25_08:11:31.246.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | CHIARA D'AMBROSIO |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-05-06 03:32:05 | ID requested | |
| ⏵ 1 | 2026-06-25 08:11:31 | announced | |
Publication List
Keyword List
| submitter keyword: LC-MS-MS,praja2, interactome |
Contact List
| Andrea Scaloni |
|---|
| contact affiliation | Proteomics, Metabolomics & Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment (ISPAAM), National Research Council, Piazzale Enrico Fermi 1, 80055 Portici (NA), Italy |
| contact email | andrea.scaloni@cnr.it |
| lab head | |
| CHIARA D'AMBROSIO |
|---|
| contact affiliation | ISPAAM CNR |
| contact email | chiara.dambrosio@cnr.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD033734 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033734
- Label: PRIDE project
- Name: Proteomic analysis of affinity-purified praja2 complexes
