PXD033582 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Targeting parvalbumin promotes M2 macrophage polarization energy expenditure in diet-induced mouse obesity models |
Description | Exercise benefits M2 macrophage polarization, energy homeostasis and protects against obesity partially through exercise-induced circulating factors. Here, by unbiased quantitative proteomics on serum samples from sedentary and exercised mice, we identify parvalbumin as a circulating factor suppressed by exercise. Parvalbumin functions as a non-competitive CSF1R antagonist to inhibit M2 macrophage activation and energy expenditure in adipose tissue. More importantly, serum concentrations of parvalbumin positively correlate with obesity in mouse and human, while treating mice with a recombinant parvalbumin blocker prevents its interaction with CSF1R and promotes M2 macrophage polarization and ameliorates diet-induced obesity. Thus, although further studies are required to assess the significance of parvalbumin in mediating the effects of exercise, our results implicate parvalbumin as a potential therapeutic strategy against obesity. |
HostingRepository | PRIDE |
AnnounceDate | 2022-05-10 |
AnnouncementXML | Submission_2022-05-10_02:14:52.419.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Shaojian Lin |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-05-04 09:10:00 | ID requested | |
⏵ 1 | 2022-05-10 02:14:52 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Mouse,serum,TMT,HPLC-MS/MS |
Contact List
Bing Luan |
contact affiliation | Department of Endocrinology, Tongji Hospital Affiliated to Tongji University, School of Medicine, Tongji University, 1239 Siping Road, Shanghai 200092, China. |
contact email | bluan@tongji.edu.cn |
lab head | |
Shaojian Lin |
contact affiliation | Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China |
contact email | shaojianlin88@126.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033582
- Label: PRIDE project
- Name: Targeting parvalbumin promotes M2 macrophage polarization energy expenditure in diet-induced mouse obesity models