PXD033277-1
PXD033277 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Antibiotic-like Activity of Atomic Layer Boron Nitride for Combating Resistant Bacteria |
| Description | The rapid global rise of antimicrobial resistance (AMR) that increasingly invalidates conventional antibiotics has become a huge threat to human health. Although nanosized antibacterial agents have been extensively explored, they cannot sufficiently discriminate between microbes and mammals, which necessitates the exploration of other antibiotic-like candidates for clinical uses. Herein, two-dimensional boron nitride (BN) nanosheets are reported to exhibit antibiotic-like activity to AMR bacteria. Interestingly, BN nanosheets had AMR-independent antibacterial activity without triggering secondary resistance in their long-term use and displayed excellent biocompatibility in mammals. Surface proteome analysis coupled with molecular dynamic simulations and Bio-Layer Interferometry revealed that BN nanosheets could rapidly interact with the key surface proteins of cell division including FtsP, EnvC, and TolB, resulting in a specific antibacterial mechanism by impairment of Z-ring constriction in cell division. Notably, BN nanosheets had a potent antibacterial effect in a lung infection model by P. aeruginosa (AMR), displaying a two-fold increment of survival rate. Overall, these results suggested that BN nanosheets could be a promising nano-antibiotic to combat resistant bacteria and prevent AMR evolution. |
| HostingRepository | jPOST |
| AnnounceDate | 2023-04-15 |
| AnnouncementXML | Submission_2023-04-14_08:00:05.913.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yanan Li |
| SpeciesList | scientific name: Escherichia coli; NCBI TaxID: 562; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-04-15 01:31:46 | ID requested | |
| ⏵ 1 | 2023-04-14 08:00:06 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: whole proteome, E.coli, antibacterial mechanism |
Contact List
| Yanan Li, Mingliang Ye | |
|---|---|
| lab head | |
| Yanan Li | |
| contact affiliation | Dalian Institute of Chemical Physics |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST001562/ |
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