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PXD033127-1

PXD033127 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHuman tau 0N4R isoform hyperphosphorylation LC-MS/MS
DescriptionSoluble aggregates of the microtubule-associated protein tau have been challenging to assemble and characterize, despite their important role in the development of tauopathies. We found that sequential hyperphosphorylation by protein kinase A in conjugation with either glycogen synthase kinase 3betaor stress activated protein kinase 4 enabled recombinant wild-type tau of isoform 0N4R to spontaneously polymerize into small amorphous aggregates in vitro. We employed tandem mass spectrometry to determine the phosphorylation sites.
HostingRepositoryPRIDE
AnnounceDate2022-04-13
AnnouncementXMLSubmission_2022-04-13_07:47:31.054.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJonathan Meng
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-04-08 13:51:44ID requested
12022-04-13 07:47:31announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: hyperphosphorylation, tau,human, LC-MS/MS
Contact List
David Klenerman
contact affiliationUniversity of Cambridge, Department of Chemistry
contact emaildk10012@cam.ac.uk
lab head
Jonathan Meng
contact affiliationUniversity of Cambridge
contact emailjxm21@cam.ac.uk
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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