PXD033020 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The resistance response of Klebsiella pneumoniae against the antimicrobial peptide PaDBS1R1 |
Description | Klebsiella pneumoniae is an antibiotic-resistant bacteria associated with severe infections, which has led to the search for new antimicrobial drugs to face these infections. Antimicrobial peptides (AMPs) are antimicrobials that exert anti-K. pneumoniae activity. Consequently, AMPs have been explored as a therapeutic option. However, similarly to other antimicrobials, K. pneumoniae can develop resistance against AMPs, although it is less frequent. Therefore, understanding the resistance mechanisms developed by K. pneumoniae against AMPs could aid in the design and development of more effective AMPs. This study aimed to identify via a label-free quantitative proteomic approach the resistance mechanisms involved in the resistance response of K. pneumoniae against the AMP PaDBS1R1. |
HostingRepository | PRIDE |
AnnounceDate | 2024-01-26 |
AnnouncementXML | Submission_2024-01-26_06:40:39.226.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Osmel Fleitas |
SpeciesList | scientific name: Klebsiella pneumoniae; NCBI TaxID: 573; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-04-06 08:51:28 | ID requested | |
⏵ 1 | 2024-01-26 06:40:40 | announced | |
Publication List
Fleitas O, Fontes W, De Souza CM, Da Costa MC, Cardoso MH, Castro MS, Sousa MV, Ricart CAO, Ramada MHS, Duque HM, Porto WF, Silva ON, Franco OL, A proteomic perspective on the resistance response of Klebsiella pneumoniae to antimicrobial peptide PaDBS1R1. J Antimicrob Chemother, 79(1):112-122(2024) [pubmed] |
10.1093/jac/dkad354; |
Keyword List
submitter keyword: NormalyzerDE, MetaMorpheus, MPLEx, G-PTM-D,Proteomics, Mass spectrometry |
Contact List
Octávio Luiz Franco, PhD |
contact affiliation | Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília, Brasília, Brazil. S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, Brazil. |
contact email | ocfranco@gmail.com |
lab head | |
Osmel Fleitas |
contact affiliation | Catholic University of Brasilia |
contact email | osmelfleitas83@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033020
- Label: PRIDE project
- Name: The resistance response of Klebsiella pneumoniae against the antimicrobial peptide PaDBS1R1