PXD033003 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Infection signaling and antimicrobial wound care in a predatory ant |
Description | Infected wounds pose a major mortality risk in animals. Injuries are particularly common in the ant Megaponera analis which raids pugnacious prey. Here we show that M. analis can determine when wounds are infected and treat them specifically. By applying a variety of antimicrobial compounds and proteins secreted from the metapleural gland to infected wounds workers reduce the mortality of infected individuals by 90%. Chemical analyses showed that wound infection is associated with specific changes in the cuticular hydrocarbon profile thereby likely allowing nestmates to diagnose the infection state of injured individuals and apply the appropriate antimicrobial treatment. This study demonstrates that the targeted use of antimicrobials to treat infected wounds, previously thought to be a uniquely human behavior, has evolved in insect societies as well. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:16:51.339.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Patrice Waridel |
SpeciesList | scientific name: Megaponera analis; NCBI TaxID: 1885322; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-04-06 07:59:10 | ID requested | |
1 | 2023-12-05 10:42:02 | announced | |
⏵ 2 | 2024-10-22 06:16:51 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: ants, antimicrobial, metapleural gland, LC-MS/MS |
Contact List
Erik Frank |
contact affiliation | Department of Ecology and Evolution, Biophore, University of Lausanne, CH-1015 Lausanne, Switzerland |
contact email | erik.frank@uni-wuerzburg.de |
lab head | |
Patrice Waridel |
contact affiliation | University of Lausanne |
contact email | patrice.waridel@unil.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033003
- Label: PRIDE project
- Name: Infection signaling and antimicrobial wound care in a predatory ant