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PXD033003

PXD033003 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInfection signaling and antimicrobial wound care in a predatory ant
DescriptionInfected wounds pose a major mortality risk in animals. Injuries are particularly common in the ant Megaponera analis which raids pugnacious prey. Here we show that M. analis can determine when wounds are infected and treat them specifically. By applying a variety of antimicrobial compounds and proteins secreted from the metapleural gland to infected wounds workers reduce the mortality of infected individuals by 90%. Chemical analyses showed that wound infection is associated with specific changes in the cuticular hydrocarbon profile thereby likely allowing nestmates to diagnose the infection state of injured individuals and apply the appropriate antimicrobial treatment. This study demonstrates that the targeted use of antimicrobials to treat infected wounds, previously thought to be a uniquely human behavior, has evolved in insect societies as well.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:16:51.339.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPatrice Waridel
SpeciesList scientific name: Megaponera analis; NCBI TaxID: 1885322;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-04-06 07:59:10ID requested
12023-12-05 10:42:02announced
22024-10-22 06:16:51announced2024-10-22: Updated project metadata.
Publication List
10.1038/S41467-023-43885-W;
Keyword List
submitter keyword: ants, antimicrobial, metapleural gland, LC-MS/MS
Contact List
Erik Frank
contact affiliationDepartment of Ecology and Evolution, Biophore, University of Lausanne, CH-1015 Lausanne, Switzerland
contact emailerik.frank@uni-wuerzburg.de
lab head
Patrice Waridel
contact affiliationUniversity of Lausanne
contact emailpatrice.waridel@unil.ch
dataset submitter
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Dataset FTP location
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