PXD033003

PXD033003 is an original dataset announced via ProteomeXchange.

Title	Infection signaling and antimicrobial wound care in a predatory ant
Description	Infected wounds pose a major mortality risk in animals. Injuries are particularly common in the ant Megaponera analis which raids pugnacious prey. Here we show that M. analis can determine when wounds are infected and treat them specifically. By applying a variety of antimicrobial compounds and proteins secreted from the metapleural gland to infected wounds workers reduce the mortality of infected individuals by 90%. Chemical analyses showed that wound infection is associated with specific changes in the cuticular hydrocarbon profile thereby likely allowing nestmates to diagnose the infection state of injured individuals and apply the appropriate antimicrobial treatment. This study demonstrates that the targeted use of antimicrobials to treat infected wounds, previously thought to be a uniquely human behavior, has evolved in insect societies as well.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:16:51.339.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Patrice Waridel
SpeciesList	scientific name: Megaponera analis; NCBI TaxID: 1885322;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-06 07:59:10	ID requested
1	2023-12-05 10:42:02	announced
⏵ 2	2024-10-22 06:16:51	announced	2024-10-22: Updated project metadata.

10.1038/S41467-023-43885-W;

submitter keyword: ants, antimicrobial, metapleural gland, LC-MS/MS

Erik Frank
contact affiliation	Department of Ecology and Evolution, Biophore, University of Lausanne, CH-1015 Lausanne, Switzerland
contact email	erik.frank@uni-wuerzburg.de
lab head
Patrice Waridel
contact affiliation	University of Lausanne
contact email	patrice.waridel@unil.ch
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD033003
     1. Label: PRIDE project
     2. Name: Infection signaling and antimicrobial wound care in a predatory ant