PXD032949 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Myocardial Injury Caused by Chronic Alcohol Exposure——A Pilot Study Based on Proteomic |
Description | Chronic alcohol exposure can cause myocardial degenerative diseases, manifested as cardiac insufficiency, arrhythmia, etc. These are defined as alcoholic cardiomyopathy (ACM). Alcohol-mediated myocardial injury has previously been studied through metabolomics, and it has been proved to be involved in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway related to the biosynthesis of unsaturated fatty acids and oxidative phosphorylation, which tentatively explored the mechanism of ACM induced by chronic drinking. To further study the myocardial damage caused by alcohol, the mouse model of ACM successfully established previously was used to perform proteomics analysis on myocardial specimens. Fifty-six differentially expressed proteins (DEPs) were identified, and they are involved in the KEGG pathway related to fatty acid biosynthesis, lipid metabolism, oxidative stress, and the development of dilated cardiomyopathy (DCM). The present study further demonstrated the underlying causes of myocardial damage caused by chronic alcohol consumption and lays the foundation for further research to clarify the underlying mechanism of ACM. |
HostingRepository | PRIDE |
AnnounceDate | 2022-08-12 |
AnnouncementXML | Submission_2022-08-12_00:14:59.303.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xiaonan Ma |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | (18)O label at both C-terminal oxygens |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-04-02 14:21:04 | ID requested | |
⏵ 1 | 2022-08-12 00:15:00 | announced | |
Publication List
Ma X, Liao Z, Li R, Xia W, Guo H, Luo J, Sheng H, Tian M, Cao Z, Myocardial Injury Caused by Chronic Alcohol Exposure-A Pilot Study Based on Proteomics. Molecules, 27(13):(2022) [pubmed] |
Keyword List
submitter keyword: alcoholic cardiomyopathy |
proteomics |
differentially expressed proteins |
KEGG pathway |
myocardial injury |
Contact List
Zhipeng Cao |
contact affiliation | China Medical University School of Forensic Medicine |
contact email | zpcao@cmu.edu.cn |
lab head | |
Xiaonan Ma |
contact affiliation | China Medical University |
contact email | 1158192730@qq.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD032949
- Label: PRIDE project
- Name: Myocardial Injury Caused by Chronic Alcohol Exposure——A Pilot Study Based on Proteomic