PXD032948-1

PXD032948 is an original dataset announced via ProteomeXchange.

Title	The signalling architecture of skeletal muscle insulin resistance
Description	Insulin resistance, the defective regulation of glucose metabolism by insulin, increases the risk of type 2 diabetes and cardiovascular disease. It is not yet known how insulin resistance remodels signalling networks in human tissues. Here, we define the signalling architecture of insulin resistance in skeletal muscle. We measured phenotypes and phosphoproteomes of insulin resistant and insulin sensitive subjects as they responded to exercise and an insulin infusion, quantifying more than 26,000 phosphosites in 114 skeletal muscle biopsies. Incorporating a temporal component to personalised phosphoproteomics identified signalling linked with the range of insulin sensitivity across the participants.
HostingRepository	PRIDE
AnnounceDate	2024-11-23
AnnouncementXML	Submission_2024-11-23_00:15:20.984.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sean Humphrey
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-02 14:19:12	ID requested
⏵ 1	2024-11-23 00:15:21	announced

10.1016/J.CMET.2024.10.020;

submitter keyword: insulin resistance, proteomics, post-translational modification, mass spectrometry, exercise, skeletal muscle, signal transduction, phosphorylation, phosphoproteomics,human

Sean Humphrey
contact affiliation	The University of Sydney, Australia
contact email	sean.j.humphrey@gmail.com
lab head
Sean Humphrey
contact affiliation	Murdoch Children's Research Institute
contact email	sean.j.humphrey@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/11/PXD032948

PRIDE project URI

• PRIDE
  1. PXD032948
     1. Label: PRIDE project
     2. Name: The signalling architecture of skeletal muscle insulin resistance