PXD032929-2

PXD032929 is an original dataset announced via ProteomeXchange.

Title	HDX-MS analysis of the mechanism of AKT1 inhibitor binding
Description	Analysis of AKT1 inhibitor binding using HDX-MS .
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:42:22.022.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	John Burke
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	impact HD

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-02 13:20:30	ID requested
1	2024-10-08 12:44:49	announced
⏵ 2	2024-10-22 05:42:22	announced	2024-10-22: Updated project metadata.

10.1016/j.str.2023.01.007;

Shaw AL, Parson MAH, Truebestein L, Jenkins ML, Leonard TA, Burke JE, ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1. Structure, 31(3):343-354.e3(2023) [pubmed]

submitter keyword: HDX-MS, AKT1, AKT DrLink, AKT DA

Dr. John E. Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
lab head
John Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/02/PXD032929

PRIDE project URI

• PRIDE
  1. PXD032929
     1. Label: PRIDE project
     2. Name: HDX-MS analysis of the mechanism of AKT1 inhibitor binding