PXD032847-1

PXD032847 is an original dataset announced via ProteomeXchange.

Title	Systematic identification of cell fate regulatory programs using a single-cell atlas of mouse development
Description	Single-cell genomics is altering our understanding of the Waddington landscape, and provides a more general representation of the state manifold. Yet, the molecular regulations behind the state manifold remain poorly understood. We construct a dynamic cell landscape of mouse lineage differentiation at the single-cell level and thereby reveal both lineage-common and lineage-specific regulatory programs during cell type maturation. We verify lineage-common regulatory programs that are universal during the development of invertebrates and vertebrates. In particular, we identify Xbp1 as an evolutionarily conserved regulator of cell fate determinations across different species. We demonstrate that Xbp1 transcriptional regulation is important for the stabilization of the genetic network for a wide range of cell types. Our results offer genetic and molecular insights into the cell fate decisions and provide resources to advance the understanding of cellular state manifolds.
HostingRepository	PRIDE
AnnounceDate	2022-04-08
AnnouncementXML	Submission_2022-04-08_01:37:43.306.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lijiang Fei
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-27 05:51:13	ID requested
⏵ 1	2022-04-08 01:37:43	announced

Dataset with its publication pending

submitter keyword: Lineage-common regulator

cell fate decision

cross species

Guoji Guo
contact affiliation	Zhejiang University
contact email	ggj@zju.edu.cn
lab head
Lijiang Fei
contact affiliation	Zhejiang University
contact email	15053291863@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD032847

PRIDE project URI

• PRIDE
  1. PXD032847
     1. Label: PRIDE project
     2. Name: Systematic identification of cell fate regulatory programs using a single-cell atlas of mouse development