PXD032807-2

PXD032807 is an original dataset announced via ProteomeXchange.

Title	The novels biomarkers for assessing clinical benefits of continuous renal replacement therapy in pediatric sepsis
Description	Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Continuous renal replacement therapy (CRRT) is regarded as an adjuvant therapy for critically ill, which removes excess fluids and clear uremic toxins, endotoxins, proteins, and inflammatory mediators efficiently. In patients with sepsis, CRRT has the advantages of maintaining hemodynamic stability, accurate fluid control, and steady acid-base and electrolyte correction. 2020 “Surviving Sepsis Campaign (SSC) international guidelines” for children suggested that CRRT should be considered in hemodynamically unstable septic patients for promoting management of fluid balance and acute kidney injury (AKI).Blood levels of cytokines (such as interleukin-8 [IL-8], tumor necrosis factor -α [TNF-α], IL-10, and IL-6) and endotoxins are often elevated in patients with sepsis. CRRT removing endotoxins and cytokines from septic patients is associated with improved patient outcomes. Our previous multicenter study indicated th
HostingRepository	iProX
AnnounceDate	2022-03-25
AnnouncementXML	Submission_2023-01-28_19:52:03.851.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shuyun Feng
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-25 01:56:15	ID requested
1	2022-03-25 01:56:33	announced
⏵ 2	2023-01-28 19:52:04	announced	2023-01-29: Update publication information.

Cui Y, Feng S, Miao H, Liu T, Shi J, Dou J, Wang C, Zhang Y, The novel biomarkers for assessing clinical benefits of continuous renal replacement therapy in pediatric sepsis: a pilot study. Clin Proteomics, 20(1):4(2023) [pubmed]

submitter keyword: continuous renal replacement therapy, pediatric sepsis, biomarkers

Chunxia Wang
contact affiliation	Shanghai Children Hospital, Shanghai Jiao Tong University School of Medicine
contact email	karencx0465@163.com
lab head
Shuyun Feng
contact affiliation	Shanghai Children Hospital, Shanghai Jiao Tong University School of Medicine
contact email	fengshuyun2020@163.com
dataset submitter

iProX dataset URI