PXD032710-1
PXD032710 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | IgA Nephropathy Proteome Profiling |
| Description | IgA nephropathy (IgAN) is a heterogeneous disease, which poses a series of challenges to accurate diagnosis and personalized therapy. Here, we present a systematic quantitative kidney tissue proteome atlas across 19 tumor-adjacent normal kidney tissues, 12 membranous nephropathy (MN) samples and 59 biopsies from IgAN patients. Consensus sub-clustering of proteome profiles divided IgAN into three subtypes (IgAN-C1, C2 and C3). Compared to IgAN-C2, the IgAN-C1, and C3 subtypes had a different regulating mechanism and exhibited higher levels of complement activation, more severe mitochondrial injury, and more significant extracellular matrix accumulation. Additionally, IgAN-C1 and C3 had worse clinical outcomes than C2 (30% serum creatinine increase as the end point, P<0.01). Overall, the novel proteomic prognostic subtyping of IgAN could help us understand the heterogeneity of IgAN and improve clinical outcomes. |
| HostingRepository | iProX |
| AnnounceDate | 2022-03-22 |
| AnnouncementXML | Submission_2022-03-22_19:49:01.329.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yang Lu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Thermo Finnigan instrument model; Orbitrap Fusion; Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-03-22 19:48:34 | ID requested | |
| ⏵ 1 | 2022-03-22 19:49:01 | announced | |
| 2 | 2023-03-29 00:31:23 | announced | 2023-03-29: Update publication information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: IgA Nephropathy, Proteomics, Classification |
Contact List
| Xiangmei Chen | |
|---|---|
| contact affiliation | First Medical Center of Chinese PLA General Hospital |
| contact email | xmchen301@126.com |
| lab head | |
| Yang Lu | |
| contact affiliation | First Medical Center of Chinese PLA General Hospital |
| contact email | lvyang1978@hotmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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