PXD032624-1

PXD032624 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Transmembrane Batten disease proteins interact with a shared network of vesicle sorting proteins, impacting synaptic composition and function
Description	Batten disease is unique among lysosomal storage disorders for the early and profound manifestation in the central nervous system, but little is known regarding potential neuron-specific roles for the disease-associated proteins. We demonstrate substantial overlap in the protein interactomes of three transmembrane Batten proteins (CLN3, CLN6, and CLN8), and that their absence leads to synaptic depletion of key partners (i.e. SNAREs and tethers) and altered synaptic SNARE complexing in vivo, demonstrating a novel shared etiology.
HostingRepository	MassIVE
AnnounceDate	2022-03-19
AnnouncementXML	Submission_2022-03-19_00:46:36.742.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexandre Rosa Campos
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	Oxidation
Instrument	Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-19 00:26:48	ID requested
⏵ 1	2022-03-19 00:46:37	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: neuronal ceroid lipofuscinosis, synaptic sorting, CLN3, CLN6, CLN8

submitter keyword: neuronal ceroid lipofuscinosis, synaptic sorting, CLN3, CLN6, CLN8

Contact List

Jill M. Weimer
contact affiliation	Sanford Research
contact email	jill.weimer@sanfordhealth.org
lab head
Alexandre Rosa Campos
contact affiliation	SBP Medical Discovery Institute
contact email	arosacampos@sbpdiscovery.org
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000089081/