PXD032312-1

PXD032312 is an original dataset announced via ProteomeXchange.

Title	Temporal Quantitative Proteomic Profiling of Murine Embryonic Heart Development
Description	Comprehensive detail of the molecular mechanisms that govern heart development is essential for identifying the etiology of congenital heart disease. We used high-throughput quantitative proteomics to measure temporal changes in the cardiac proteome at eight critical stages of murine embryonic heart development. We identified more than 7,300 proteins, assessed global temporal changes in protein expression, identified cardiac protein interaction networks, and linked protein dynamics with molecular pathways. Using this dataset, we identified and defined a function for the mevalonate pathway in the regulation of embryonic cardiomyocyte proliferation and cell signaling. Overall, our proteomic datasets are an invaluable resource for studying molecular events that regulate embryonic heart development and that contribute to congenital heart disease.
HostingRepository	PRIDE
AnnounceDate	2023-04-06
AnnouncementXML	Submission_2023-04-06_14:26:03.464.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	LauraHerring
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-16 03:57:36	ID requested
⏵ 1	2023-04-06 14:26:03	announced

Dataset with its publication pending

submitter keyword: TMT, development, quantitative proteomics,heart

FrankConlon
contact affiliation	Department of Biology, UNC-Chapel Hill
contact email	frank_conlon@med.unc.edu
lab head
LauraHerring
contact affiliation	UNC-Chapel Hill
contact email	laura_herring@med.unc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD032312

PRIDE project URI

• PRIDE
  1. PXD032312
     1. Label: PRIDE project
     2. Name: Temporal Quantitative Proteomic Profiling of Murine Embryonic Heart Development