PXD032306-1
PXD032306 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Src heterodimerically activates Lyn or Fyn to serve as targets for esophageal squamous cell carcinoma (ESCC) diagnosis and treatment |
| Description | we combined phosphoproteomics and several cellular and molecular biologic strategies to identify that Src specifically interacted with the members of Src-family kinases (SFKs), such as Fyn or Lyn to form heterodimers, and subsequently phosphorylate the tyrosine sites in SH2 and kinase domains, which critically contributed to the ESCC malignancy. |
| HostingRepository | iProX |
| AnnounceDate | 2022-03-15 |
| AnnouncementXML | Submission_2023-05-04_19:02:59.826.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jing Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | phosphorylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-03-15 20:13:56 | ID requested | |
| ⏵ 1 | 2023-05-04 19:03:00 | announced | |
| 2 | 2023-12-25 19:58:14 | announced | 2023-12-26: Update information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ESCC, SRC, heterodimer |
Contact List
| Qimin Zhan | |
|---|---|
| contact affiliation | Beijing Cancer Hospital |
| contact email | zhanqimin@bjmu.edu.cn |
| lab head | |
| Jing Zhang | |
| contact affiliation | Beijing Cancer Hospital |
| contact email | 15810815756@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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