PXD032291-2

PXD032291 is an original dataset announced via ProteomeXchange.

Title	Noninvasive urinary protein signatures associated with colorectal cancer diagnosis and metastasis
Description	Colorectal cancer is the 3rd commonly diagnosed cancer (10.2%) and 2nd cause of cancer death (9.2%) in all cancers.There will be estimated 1.8 million new colorectal cancer cases and 0.9 million colorectal cancer deaths in 20181. As the 5th incidence rates and mortality rates cancer in china, colorectal cancer incidence rates has increased from 1990 to 20112,3. CRC is concidered as a muti-step progress diseases4, patients with precursors lesions and early stage CRC can get great benefit from surgical treatment, colonoscope can detect visiable early dieases but not suitable for large-scale screening5, because of the poor sensitivity or specificity, blood carcinoembryonic antigen(CEA)6,7 and fecal blood testing(FOBT)8 provide limited help. There is no standard biomarker predicting CRC lymph node and liver metastasis4, although It’s very valuable for patients and docter before and after surgery9. Liver is the main site for colorectal cancer metastasis10, hepatic resection is the only treatment and successful for CRC-LM11, Unfortunately, over 50% of patients who get hepatic resection develop recurrences11, since then it’s hlepful to find biomarkers for monitoring CRC metastasis, blood CEA has been accepted as indicator of CRC progress12, in current study, we aim to explore a more convient and presion way for monitoring CRC metastasis.
HostingRepository	iProX
AnnounceDate	2022-03-15
AnnouncementXML	Submission_2023-02-20_19:22:21.808.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zongpan Jing
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos; TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-15 00:54:47	ID requested
1	2022-03-15 00:55:07	announced
⏵ 2	2023-02-20 19:22:22	announced	2023-02-21: Update information.

Sun Y, Guo Z, Liu X, Yang L, Jing Z, Cai M, Zheng Z, Shao C, Zhang Y, Sun H, Wang L, Wang M, Li J, Tian L, Han Y, Zou S, Gao J, Zhao Y, Nan P, Xie X, Liu F, Zhou L, Sun W, Zhao X, Noninvasive urinary protein signatures associated with colorectal cancer diagnosis and metastasis. Nat Commun, 13(1):2757(2022) [pubmed]

submitter keyword: CRC urine PRM

Xiaohang Zhao
contact affiliation	State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
contact email	zhaoxh@cicams.ac.cn
lab head
Zongpan Jing
contact affiliation	State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
contact email	1129964712@qq.com
dataset submitter

iProX dataset URI