PXD032189-1

PXD032189 is an original dataset announced via ProteomeXchange.

Title	Integrated Network Pharmacology and Proteomics to Reveal the Molecular Therapeutic Effects of Buyang Huanwu Decoction on Ischemic Stroke
Description	Ischemic stroke (IS), as a common cerebrovascular disease, is characterized by high disability, mortality, recurrence, and complications. Studies have shown that Buyang Huanwu Decoction (BHD) can impact the treatment of acute cerebral infarction, subsequent recovery, and sequelae. However, the mechanism of action of BHD in IS treatment remains unclear. To this end, we applied a combined network pharmacology and proteomics approach to investigate the mechanism of action of BHD. First, the chemical components of BHD were revealed by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOFMS/MS). The molecular mechanism of BHD in treating IS was preliminarily elucidated through a network pharmacological approach. Subsequently, proteomic studies were used to explore the biomarkers of BHD in IS treatment
HostingRepository	iProX
AnnounceDate	2022-03-11
AnnouncementXML	Submission_2022-03-10_19:07:20.146.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yingying He
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	TMT6plex reporter fragment
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-10 19:07:04	ID requested
⏵ 1	2022-03-10 19:07:21	announced

He Y, Zheng H, Zhong L, Zhong N, Wen G, Wang L, Zhang Y, Identification of Active Ingredients of Huangqi Guizhi Wuwu Decoction for Promoting Nerve Function Recovery After Ischemic Stroke Using HT22 Live-Cell-Based Affinity Chromatography Combined with HPLC-MS/MS. Drug Des Devel Ther, 15():5165-5178(2021) [pubmed]

submitter keyword: Proteomics, Buyang Huanwu Decoction, Ischemic Stroke

Lisheng Wang
contact affiliation	Guangzhou University of Chinese Medicine
contact email	wlis68@126.com
lab head
Yingying He
contact affiliation	Guangzhou University of Chinese Medicine
contact email	13189086632@163.com
dataset submitter

iProX dataset URI