PXD032093-1
PXD032093 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | ILF3 safeguards telomere from aberrant homologous recombination as a telomeric R-loop reader |
| Description | Here we found that ILF3 prefers to bind telomere R-loops and protects telomere from aberrant homologous recombination. ILF3 knockout induces TERRA aggregation onto telomere and activates telomere DNA damage response (DDR). Furthermore, ILF3 deficiency disrupts telomere homeostasis and induces abnormal ALT-mediated telomere lengthening |
| HostingRepository | iProX |
| AnnounceDate | 2022-03-04 |
| AnnouncementXML | Submission_2023-10-15_19:12:50.015.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chuanle Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-03-06 21:13:37 | ID requested | |
| ⏵ 1 | 2023-10-15 19:12:50 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ILF3, RNA, DNA hybrids, telomeric R-loop |
Contact List
| Yan Huang | |
|---|---|
| contact affiliation | Sun Yat-sen University |
| contact email | huangy336@mail.sysu.edu.cn |
| lab head | |
| Chuanle Wang | |
| contact affiliation | Sun Yat-sen University |
| contact email | 1415849898@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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