<<< Full experiment listing

PXD032093-1

PXD032093 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleILF3 safeguards telomere from aberrant homologous recombination as a telomeric R-loop reader
DescriptionHere we found that ILF3 prefers to bind telomere R-loops and protects telomere from aberrant homologous recombination. ILF3 knockout induces TERRA aggregation onto telomere and activates telomere DNA damage response (DDR). Furthermore, ILF3 deficiency disrupts telomere homeostasis and induces abnormal ALT-mediated telomere lengthening
HostingRepositoryiProX
AnnounceDate2022-03-04
AnnouncementXMLSubmission_2023-10-15_19:12:50.015.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChuanle Wang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-03-06 21:13:37ID requested
12023-10-15 19:12:50announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: ILF3, RNA, DNA hybrids, telomeric R-loop
Contact List
Yan Huang
contact affiliationSun Yat-sen University
contact emailhuangy336@mail.sysu.edu.cn
lab head
Chuanle Wang
contact affiliationSun Yat-sen University
contact email1415849898@qq.com
dataset submitter
Full Dataset Link List
iProX dataset URI