PXD032039 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | DUSP1/6-mediated phosphorylation signaling events in CLL |
Description | Despite strong evidence of a significant role of MAPK signaling in chronic lymphocytic leukemia (CLL), phosphatase development and progression, this pathway is up to date not targeted in CLL therapy and available BRAF and MEK inhibitors are not efficient in reducing tumor progression. In this study, we evaluated the effects of targeted hyperactivation of the MAPK signaling pathway in CLL. |
HostingRepository | PRIDE |
AnnounceDate | 2023-10-09 |
AnnouncementXML | Submission_2023-10-09_03:57:57.704.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | PieroGiansanti |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-03-03 11:55:49 | ID requested | |
⏵ 1 | 2023-10-09 03:57:58 | announced | |
2 | 2023-11-14 09:05:52 | announced | 2023-11-14: Updated project metadata. |
Publication List
Ecker V, Brandmeier L, Stumpf M, Giansanti P, Moreira AV, Pfeuffer L, Fens MHAM, Lu J, Kuster B, Engleitner T, Heidegger S, Rad R, Ringshausen I, Zenz T, Wendtner CM, M, ΓΌ, schen M, Jellusova J, Ruland J, Buchner M, Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression. Cell Rep, 42(10):113017(2023) [pubmed] |
Keyword List
submitter keyword: phosphoproteomics, DUSP1, DUSP6, apoptosis, DNA damage response, chronic lymphocytic leukemia |
Contact List
BernhardKuster |
contact affiliation | Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany |
contact email | kuster@tum.de |
lab head | |
PieroGiansanti |
contact affiliation | Technical University of Munich |
contact email | piero.giansanti@tum.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD032039 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD032039
- Label: PRIDE project
- Name: DUSP1/6-mediated phosphorylation signaling events in CLL