PXD031979-1

PXD031979 is an original dataset announced via ProteomeXchange.

Title	Multi-platform omics analysis reveals molecular signatures for pathogenesis and activity of systemic lupus erythematosus
Description	Systemic lupus erythematosus (SLE) is a complex autoimmune disease with heterogeneous clinical manifestations and the pathogenesis of SLE is still unclear. Various omics results have been reported for SLE, but the molecular hallmarks of SLE, especially in patients with different disease activity, using an integrated multi-omics approach have not been fully investigated. Here, we collected blood samples from 10 healthy controls (HCs) and 40 SLE patients with different clinical activity including inactive (IA), low activity (LA), and high activity (HA). Using an integrative analysis of proteomic, metabolomic and lipidomic profiles, we report the multi-omics landscape for SLE. The molecular changes suggest that both the complement system and the inflammatory response were activated in SLEs and were associated with disease activity. Additionally, activation of the immunoglobulin mediated immune response were observed in the LA stage of the disease, however this immune response was suppressed slightly in the HA stage. Finally, an imbalance in lipid metabolism, especially in sphingolipid metabolism, accompanied with dysregulated apolipoproteins were observed to contribute to the disease activity of SLE. The multi-omics data presented in this study and the characterization of peripheral blood from SLE patients may thus help provide important clues regarding the pathogenesis of SLE.
HostingRepository	iProX
AnnounceDate	2022-03-02
AnnouncementXML	Submission_2022-03-01_19:55:45.488.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-01 19:55:03	ID requested
⏵ 1	2022-03-01 19:55:45	announced

Dataset with its publication pending

submitter keyword: Systemic lupus erythematosus, proteomic, metabolomic, lipidomic, pathogenesis

Yi Wang
contact affiliation	Experimental Research Center, Capital Institute of Pediatrics
contact email	wildwolf0101@163.com
lab head
Yi Wang
contact affiliation	Capital Institute of Pediatrics
contact email	wildwolf0101@163.com
dataset submitter

iProX dataset URI