PXD031890-1

PXD031890 is an original dataset announced via ProteomeXchange.

Title	Regulation of stress signaling by SCD1
Description	Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation, controlled by stearoyl-CoA desaturase (SCD)1, prevents cytotoxic stress but the mechanisms are diffuse. We found that SCD1 inhibition alters the levels of proteins phosphorylated at tyrosine in fibroblasts. Major regulated proteins were identified following immunoprecipitation using an anti-phospho-tyrosine antibody and subsequent proteomic analysis.
HostingRepository	PRIDE
AnnounceDate	2022-03-24
AnnouncementXML	Submission_2022-03-24_08:41:58.041.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andreas Koeberle
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	alkylated residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-24 10:29:25	ID requested
⏵ 1	2022-03-24 08:41:58	announced
2	2022-05-31 01:42:50	announced	2022-05-31: Updated publication reference for PubMed record(s): 35624087.

Dataset with its publication pending

submitter keyword: LC-MSE, mouse fibroblasts, stress signaling, monounsaturated fatty acid, phospholipid

Andreas Koeberle
contact affiliation	Michael Popp Institute, University of Innsbruck, Austria
contact email	andreas.koeberle@uibk.ac.at
lab head
Andreas Koeberle
contact affiliation	Michael Popp Institute, University of Innsbruck
contact email	andreas.koeberle@uibk.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD031890

PRIDE project URI

• PRIDE
  1. PXD031890
     1. Label: PRIDE project
     2. Name: Regulation of stress signaling by SCD1