PXD031878-2

PXD031878 is an original dataset announced via ProteomeXchange.

Title	Oxygen and hormone effect on rat oligodrendrocyte progenitor cell line (OLN93)
Description	Hyperoxia is known to cause cerebral white matter injury in preterm infants. Preterm birth is also associated with sudden hormonal changes which includes drop of estrogen level and increased postnatal production of fetal zone steroids (FZS). Therefore, we investigated the effect of hyperoxia (80% O2) and the subsequent administration of FZS on the proteins of immature oligodendrocytes using the OLN93 (rat-derived OPC) cell line as an experimental model. We demonstrate that hyperoxia has a negative effect on migration and associated signalling pathways, and that FZS and estrogen have distinct effects on these alterations.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:36:10.289.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Elke Hammer
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-24 10:14:03	ID requested
1	2022-05-16 03:51:26	announced
⏵ 2	2024-10-22 05:36:10	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Oligodendrocyte progenitor cell line, hyperoxia , fetal zone steroids, LC-MS/MS

Elke Hammer
contact affiliation	Dr. Elke Hammer Universitätsmedizin Greifswald Interfakultäres Institut für Genetik und Funktionelle Genomforschung Abteilung für Funktionelle Genomforschung Felix-Hausdorff-Straße 8 17487 Greifswald
contact email	hammer@uni-greifswald.de
lab head
Elke Hammer
contact affiliation	Dept. of Functional Genomics
contact email	hammer@uni-greifswald.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD031878

PRIDE project URI

• PRIDE
  1. PXD031878
     1. Label: PRIDE project
     2. Name: Oxygen and hormone effect on rat oligodrendrocyte progenitor cell line (OLN93)