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PXD031868 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMouse Articular chondrocyte LC-MSMS of wild-type, miR-26a -/- and cartilage-specific miR-23ab clusters knockout mice
DescriptionTo reveal the potential regulation target genes of miR-26a and miR-23a/b clusters in articular chondrocytes, we performed a multi-omics analysis of LC-MSMS and RNA-seq using cultured chondrocytes samples, which were primarily isolated from 3-week-old wild-type, miR-26a -/- (with or without miR-26a mimic transfection afterwards) or miR-23a/b cluster flox/flox;Col2a1-cre mice. For LC-MSMS, protein from TRIZOL reagent was extracted, nanoLC-MSMS was performed. An expression list was made to further explore the regulation targets of miR-26a and miR-23a/b clusters.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-02-24 01:06:21ID requested
12023-01-24 19:33:33announced
22023-11-14 08:33:25announced2023-11-14: Updated project metadata.
Publication List
Fujiwara Y, Ding C, Sanada Y, Yimiti D, Ishikawa M, Nakasa T, Kamei N, Imaizumi K, Lotz MK, Akimoto T, Miyaki S, Adachi N, miR-23a/b clusters are not essential for the pathogenesis of osteoarthritis in mouse aging and post-traumatic models. Front Cell Dev Biol, 10():1043259(2022) [pubmed]
Keyword List
submitter keyword: LC-MSMS, Chondrocyte,Mouse, miR-26a, miR-23 cluster
Contact List
contact affiliationDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan (lab head)
contact emailmiyaki@hiroshima-u.ac.jp
lab head
contact affiliationHiroshima University
contact emaildingchenyang@hiroshima-u.ac.jp
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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