PXD031830-1

PXD031830 is an original dataset announced via ProteomeXchange.

Title	Proteome-wide pulse labeling reveals amyloid-impaired protein degradation in Alzheimer’s disease
Description	We here present a large-scale proteome-wide profiling of protein turnover in Alzheimer's disease mice model. We integrated in vivo pulse-SILAC labeling and TMT multiplexing with novel mass spectrometry to precisely measure protein half-lives.
HostingRepository	PRIDE
AnnounceDate	2024-10-29
AnnouncementXML	Submission_2024-10-28_17:16:06.779.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ka Yang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	6x(13)C labeled residue; monohydroxylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-22 09:06:55	ID requested
⏵ 1	2024-10-28 17:16:07	announced

Dataset with its publication pending

submitter keyword: Alzheimer’s disease, TMT, protein turnover, SIALC

Junmin Peng
contact affiliation	St Jude Children's Research Hospital
contact email	junmin.peng@stjude.org
lab head
Ka Yang
contact affiliation	St Jude Children's Research Hospital
contact email	yangka1990@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD031830

PRIDE project URI

• PRIDE
  1. PXD031830
     1. Label: PRIDE project
     2. Name: Proteome-wide pulse labeling reveals amyloid-impaired protein degradation in Alzheimer’s disease