PXD031739-1

PXD031739 is an original dataset announced via ProteomeXchange.

Title	Effects on the lipid metabolism of Atlantic cod (Gadus morhua) after in vivo exposure with Ppar agonists
Description	Lipid metabolism is essential in maintaining energy homeostasis in multicellular organisms. In vertebrates, the peroxisome proliferator-activated receptors (PPARs, NR1C) regulate the expression of many genes involved in these processes. Four Ppar subtypes from Atlantic cod (Gadus morhua) were recently cloned and characterized. However, the downstream regulatory role of Ppars in cod lipid metabolism is presently not well understood or described. Here we study the involvement of Atlantic cod Ppar subtypes in systemic regulation of lipid metabolism using the model agonists WY14,643, GW501516, and tetradecylthioacetic acid, employing a multiple omics approach after an in vivo exposure situation.
HostingRepository	PRIDE
AnnounceDate	2022-09-20
AnnouncementXML	Submission_2022-09-20_05:58:08.579.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Odd Andre Karlsen
SpeciesList	scientific name: Gadus morhua (Atlantic cod); NCBI TaxID: 8049;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-17 04:17:07	ID requested
⏵ 1	2022-09-20 05:58:08	announced

Dataset with its publication pending

submitter keyword: Atlantic cod, WY14643, GW501516, tetradecylthioacetic acid, liver, TMT-proteomics

Odd André Karlsen
contact affiliation	Department of Biological Sciences University of Bergen Norway
contact email	odd.karlsen@uib.no
lab head
Odd Andre Karlsen
contact affiliation	Department of Biology, University of Bergen, Norway
contact email	odd.karlsen@uib.no
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD031739
     1. Label: PRIDE project
     2. Name: Effects on the lipid metabolism of Atlantic cod (Gadus morhua) after in vivo exposure with Ppar agonists