PXD031595-2
PXD031595 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Urinary proteomics analysis of active vitiligo patients |
| Description | Vitiligo is a common acquired skin disorder caused by immune-mediated destruction of epidermal melanocytes. Systemic glucocorticoids (GCs) have been used to prevent the progression of active vitiligo, with 8.2%–56.2% of patients insensitive to this therapy. Currently, there is a lack of biomarkers that can accurately predict and evaluate treatment responses. The goal of this study was to identify candidate urinary protein biomarkers to predict the efficacy of GCs treatment in active vitiligo patients and monitor the disease. In the present study, we aimed to identify urinary biomarkers that could predict and monitor the efficacy of steroid treatment. Urine samples were collected from the treatment-resistance group and treatment-effective group before and after GCs treatment and randomly divided into a discovery group and validation group. Differentially expressed proteins were determined using proteomic analysis. |
| HostingRepository | iProX |
| AnnounceDate | 2022-02-11 |
| AnnouncementXML | Submission_2022-10-12_19:42:18.201.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuetong Qian |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-02-10 18:42:18 | ID requested | |
| 1 | 2022-02-10 18:42:52 | announced | |
| ⏵ 2 | 2022-10-12 19:42:19 | announced | 2022-10-13: Update publication information. |
Publication List
| Qian YT, Liu XY, Sun HD, Xu JY, Sun JM, Liu W, Chen T, Liu JW, Tan Y, Sun W, Ma DL, Urinary Proteomics Analysis of Active Vitiligo Patients: Biomarkers for Steroid Treatment Efficacy Prediction and Monitoring. Front Mol Biosci, 9():761562(2022) [pubmed] |
Keyword List
| submitter keyword: active vitiligo, urinary proteomics, biomarkers, glucocorticoids resistance |
Contact List
| Wei Sun | |
|---|---|
| contact affiliation | Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine |
| contact email | sunwei1018@sina.com |
| lab head | |
| Yuetong Qian | |
| contact affiliation | Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Skin and Immune Diseases |
| contact email | qyuetong@sohu.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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