PXD031500-1

PXD031500 is an original dataset announced via ProteomeXchange.

Title	An interactive mass spectrometry atlas of histone posttranslational modifications in T-cell acute leukemia
Description	The holistic nature of omics studies makes them ideally suited to generate hypotheses on health and disease. Sequencing-based genomics and mass spectrometry (MS)-based proteomics are linked through epigenetic regulation mechanisms. However, epigenomics is currently focused on DNA methylation status using sequencing technologies, while studying histone posttranslational modifications (hPTMs) using MS is lagging, in part because reuse of raw data is impractical. Yet, it is established that targeting these hPTMs using epidrugs is a promising research avenue in cancer treatment. Therefore, we present the most comprehensive MS-based preprocessed hPTM atlas to date, including 21 T-cell acute lymphoblastic leukemia cell lines. We present the data in an intuitive and browsable single licensed Progenesis QIP project and provide all essential quality metrics, allowing users to assess the quality of the data, edit individual peptides, try novel annotation algorithms and export both peptide and protein data for downstream analyses, exemplified by the PeptidoformVisualization tool. This dataset sets the stage for generalizing MS-based histone analysis and provides the first reusable histone dataset for epidrug development.
HostingRepository	PanoramaPublic
AnnounceDate	2022-02-11
AnnouncementXML	Submission_2022-02-11_16:45:23.928.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bart Van Puyvelde
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 6600; TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-08 18:46:27	ID requested
⏵ 1	2022-02-11 16:45:24	announced

no publication

submitter keyword: Leukemia, T-ALL, Epigenetics, Histone post-translational modifications, LC-MS

Maarten Dhaenens
contact affiliation	ProGenTomics, Laboratory of Pharmaceutical Biotechnology, Ghent University
contact email	maarten.dhaenens@ugent.be
lab head
Bart Van Puyvelde
contact affiliation	ProGenTomics, Laboratory of Pharmaceutical Biotechnology, Ghent University
contact email	bart.vanpuyvelde@ugent.be
dataset submitter

Panorama Public dataset URI