PXD031500
PXD031500 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | An interactive mass spectrometry atlas of histone posttranslational modifications in T-cell acute leukemia |
| Description | The holistic nature of omics studies makes them ideally suited to generate hypotheses on health and disease. Sequencing-based genomics and mass spectrometry (MS)-based proteomics are linked through epigenetic regulation mechanisms. However, epigenomics is currently focused on DNA methylation status using sequencing technologies, while studying histone posttranslational modifications (hPTMs) using MS is lagging, in part because reuse of raw data is impractical. Yet, it is established that targeting these hPTMs using epidrugs is a promising research avenue in cancer treatment. Therefore, we present the most comprehensive MS-based preprocessed hPTM atlas to date, including 21 T-cell acute lymphoblastic leukemia cell lines. We present the data in an intuitive and browsable single licensed Progenesis QIP project and provide all essential quality metrics, allowing users to assess the quality of the data, edit individual peptides, try novel annotation algorithms and export both peptide and protein data for downstream analyses, exemplified by the PeptidoformVisualization tool. This dataset sets the stage for generalizing MS-based histone analysis and provides the first reusable histone dataset for epidrug development. |
| HostingRepository | PanoramaPublic |
| AnnounceDate | 2022-02-11 |
| AnnouncementXML | Submission_2022-02-11_16:45:23.928.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Bart Van Puyvelde |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | TripleTOF 6600; TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-02-08 18:46:27 | ID requested | |
| ⏵ 1 | 2022-02-11 16:45:24 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Leukemia, T-ALL, Epigenetics, Histone post-translational modifications, LC-MS |
Contact List
| Maarten Dhaenens | |
|---|---|
| contact affiliation | ProGenTomics, Laboratory of Pharmaceutical Biotechnology, Ghent University |
| contact email | maarten.dhaenens@ugent.be |
| lab head | |
| Bart Van Puyvelde | |
| contact affiliation | ProGenTomics, Laboratory of Pharmaceutical Biotechnology, Ghent University |
| contact email | bart.vanpuyvelde@ugent.be |
| dataset submitter | |
Full Dataset Link List
| Panorama Public dataset URI |
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