PXD031485 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation. |
Description | Follicles of polycystic ovaries (PCO) often become arrested in early antral stages at around 3 to 11 mm in diameter. The condition disturbs dominant follicle selection and may result in altered ovulation and anovulation. During the growth and development of human follicles, the follicular fluid (FF) constitutes the avascular microenvironment in which the oocyte develops and acts as a vehicle for hormone signaling between cues from circulation and follicular cells. Previous proteomics studies performed on FF from women with polycystic ovarian syndrome (PCOS) have revealed information on the protein changes associated with the pathophysiology of this disorder. However, these studies have been conducted on FF samples obtained in connection with oocyte pick-up during ovarian stimulation right at the time of ovulation and are limited to follicular conditions during the follicular phase of the menstrual cycle. This study aimed to detect proteomic alterations in FF from human small antral follicles (hSAF) obtained from women with PCO as compared to normal women. |
HostingRepository | PRIDE |
AnnounceDate | 2022-04-07 |
AnnouncementXML | Submission_2022-04-07_03:34:17.770.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Indira Pla Parada |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-02-07 07:36:22 | ID requested | |
⏵ 1 | 2022-04-07 03:34:18 | announced | |
2 | 2023-11-14 08:55:08 | announced | 2023-11-14: Updated project metadata. |
Publication List
Pla I, Sanchez A, Pors SE, Kristensen SG, Appelqvist R, Sahlin KB, Marko-Varga G, Andersen CY, Malm J, Proteomic Alterations in Follicular Fluid of Human Small Antral Follicles Collected from Polycystic Ovaries-A Pilot Study. Life (Basel), 12(3):(2022) [pubmed] |
10.1093/HUMREP/DEAA335; |
Keyword List
submitter keyword: follicular fluid, small antral follicles, proteomics, oocyte maturation. |
Contact List
Johan Malm |
contact affiliation | Clinical Chemistry, Department of Translational Medicine, Lund University, Skane University Hospital Malmö, 205 02 Malmö, Sweden. |
contact email | johan.malm@med.lu.se |
lab head | |
Indira Pla Parada |
contact affiliation | Lund university |
contact email | indira.pla_parada@med.lu.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD031485
- Label: PRIDE project
- Name: Proteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation.