PXD031456-1

PXD031456 is an original dataset announced via ProteomeXchange.

Title	Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life
Description	The cytosolic molecular chaperone Hsp90 is essential for eukaryotic life. It is involved in multiple branches of proteostasis and as a molecular capacitor in morphological evolution. Although reduced Hsp90 levels cause phenotypic variations and correlate with aging, whether eukaryotic cells and organisms can tune Hsp90 levels to alleviate physiologically accumulated stress is unknown. To begin to explore this question, we investigated whether and how mice adapt to the deletion of three out of four alleles encoding cytosolic Hsp90, one Hsp90β allele being the only remaining one. Here we have analysed the proteome of mouse tissues (brain, liver, muscle) corresponding to different Hsp90 genotypes, as well as HEK293 cell clones that were knock-out for Hsp90α/β.
HostingRepository	PRIDE
AnnounceDate	2022-09-20
AnnouncementXML	Submission_2022-09-20_05:18:33.086.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manfredo Quadroni
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-05 13:34:49	ID requested
⏵ 1	2022-09-20 05:18:33	announced

Dataset with its publication pending

submitter keyword: Hsp90α, Hsp90β, proteostasis, stress response, stress adaptation, senescence, aging, natural selection, development.

Didier Picard
contact affiliation	Département de Biologie Cellulaire, Université de Genève
contact email	didier.picard@unige.ch
lab head
Manfredo Quadroni
contact affiliation	University of Lausanne
contact email	manfredo.quadroni@unil.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/09/PXD031456

PRIDE project URI

• PRIDE
  1. PXD031456
     1. Label: PRIDE project
     2. Name: Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life