PXD031441 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A conserved module regulates receptor kinase signaling in immunity and development |
Description | Ligand recognition by cell-surface receptors underlies development and immunity in both animals and plants. Modulating receptor signaling is critical for appropriate cellular responses but the mechanisms ensuring this are poorly understood. Here, we show that signaling by plant receptors for pathogen-associated molecular patterns (PAMPs) in immunity and CLAVATA3/EMBRYO SURROUNDING REGION-RELATED peptides (CLEp) in development employs a similar regulatory module. In the absence of ligand, signaling is dampened through association with specific type-2C protein phosphatases (PP2Cs). Upon activation, PAMP and CLEp receptors phosphorylate divergent cytosolic kinases, which, in turn, phosphorylate the phosphatases, thereby promoting receptor signaling. Our work reveals a regulatory circuit shared between immune and developmental receptor signaling, which may have broader important implications for plant receptor kinase-mediated signaling in general. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:55:19.873.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD031441 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | FRank Menke |
SpeciesList | scientific name: Escherichia coli; NCBI TaxID: 562; |
ModificationList | phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-02-04 15:28:10 | ID requested | |
1 | 2022-05-04 06:52:30 | announced | |
⏵ 2 | 2023-11-14 08:55:20 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Arabidopsis, Receptor-like cytoplasmic kinases, Poltergeist-like phosphatase,in vitro kinase assay |
Contact List
Frank L.H. Menke |
contact affiliation | The Sainsbury Laboratory |
contact email | frank.menke@tsl.ac.uk |
lab head | |
FRank Menke |
contact affiliation | the Sainsbury laboratory |
contact email | Frank.Menke@tsl.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD031441
- Label: PRIDE project
- Name: A conserved module regulates receptor kinase signaling in immunity and development