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PXD031199-1

PXD031199 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA phylogenomic approach to explore the Aspergillus fumigatus conidia surforme and its role in pathogenesis
DescriptionAspergillus fumigatus is the most important pulmonary fungal pathogen. Virulence has evolved several times in the section Aspergillii. However, there are species in this section, such as A. fischerii and A. oerlinghausensis, that are very closely related to A. fumigatus but are not reported as pathogens. By using trypsin shaving, we have identified the proteins on the conidial surface of conidia and swollen conidia of A. fumigatus, A. fischeri, A. oerlinghausensis, and A. lentulus. We have identified about 900 proteins in all four species and shown 52 that are unique in A. fumigatus. Both A. fischerii and A. oerlinghausensis have homologues for most of these proteins. However, they are not expressed in the conidia and and could reflect specific A. fumigatus traits important for infection and/or immune evasion.
HostingRepositoryPRIDE
AnnounceDate2024-06-26
AnnouncementXMLSubmission_2024-06-26_04:59:40.469.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterThomas Krüger
SpeciesList scientific name: Neosartorya fumigata (Aspergillus fumigatus); NCBI TaxID: 746128; scientific name: Aspergillus oerlinghausenensis; NCBI TaxID: 1774284; scientific name: Neosartorya fischeri; NCBI TaxID: 36630; scientific name: Aspergillus lentulus; NCBI TaxID: 293939;
ModificationListacetylated residue; monohydroxylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-01-24 03:18:03ID requested
12024-06-26 04:59:40announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: conidia, asparaginase, macrophages,Aspergilli, surfome
Contact List
Axel A. Brakhage
contact affiliationDepartment of Molecular and Applied Microbiology Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Germany
contact emailaxel.brakhage@leibniz-hki.de
lab head
Thomas Krüger
contact affiliationLeibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute
contact emailthomas.krueger@leibniz-hki.de
dataset submitter
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Dataset FTP location
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