PXD031174-1

PXD031174 is an original dataset announced via ProteomeXchange.

Title	Aging-Associated Changes in CSF Protein Abundances and Structures Revealed by a Modified LiP-MS Screen
Description	We performed LiP-MS on CSF from young and old mice with a modified analysis pipeline. We found 38 protein groups that change in abundance with aging, most dominantly immunoglobulins of the IgM subclass. We discovered six high-confidence candidates that appeared to change in structure with aging.
HostingRepository	PRIDE
AnnounceDate	2022-08-22
AnnouncementXML	Submission_2022-08-22_13:52:29.447.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Steven Shuken
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	amidated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-22 09:54:23	ID requested
⏵ 1	2022-08-22 13:52:29	announced
2	2023-11-14 08:54:12	announced	2023-11-14: Updated project metadata.

10.1038/S43587-022-00196-X;

submitter keyword: Mouse, Human, Cerebrospinal Fluid, CSF, Limited Proteolysis-Mass Spectrometry, LiP-MS, Aging, Alzheimer's Disease, AD

Tony Wyss-Coray
contact affiliation	Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA
contact email	twc@stanford.edu
lab head
Steven Shuken
contact affiliation	Department of Cell Biology, Harvard Medical School
contact email	srshuken@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD031174

PRIDE project URI

• PRIDE
  1. PXD031174
     1. Label: PRIDE project
     2. Name: Aging-Associated Changes in CSF Protein Abundances and Structures Revealed by a Modified LiP-MS Screen