PXD031029-1
PXD031029 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nuclear condensation of CDYL links histone crotonylation and cystogenesis in autosomal dominant polycystic kidney disease |
| Description | We identify the Kcr sites on histones that are targeted by CDYL in ADPKD cells (WT9-12 cells). We chose to knock out CDYL in WT 9-12 cells (CDYL KO) through CRISPR/Cas9-mediated gene editing to increase the overall levels of histone Kcr. We quantified Kcr modifications on different histone residues in CDYL KO versus parental WT 9-12 cells (control) using high-resolution liquid chromatography tandem mass spectrometry (LC-MS/MS)-based proteomics analysis |
| HostingRepository | iProX |
| AnnounceDate | 2022-01-17 |
| AnnouncementXML | Submission_2022-01-17_03:51:15.033.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xinyi Cao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-01-17 03:50:50 | ID requested | |
| ⏵ 1 | 2022-01-17 03:51:15 | announced | |
| 2 | 2023-09-06 23:59:49 | announced | 2023-09-07: Update publication information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: CDYL, Histone Crotonylation, WT9-12 cells |
Contact List
| Yupeng Chen | |
|---|---|
| contact affiliation | Tianjin Medical University |
| contact email | ychen@tmu.edu.cn |
| lab head | |
| Xinyi Cao | |
| contact affiliation | Tianjin Medical University |
| contact email | xy_cao@tmu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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