PXD030983-1

PXD030983 is an original dataset announced via ProteomeXchange.

Title	Mass spectrometry-based draft of the mouse proteome
Description	Quantitative draft map of the proteomes of 41 healthy tissues of the animal model Mus musculus and a panel of 66 murine pancreatic ductal adenocarcinoma cell lines and. Our in-depth analysis provides evidence for proteins encoded by >16,000 genes (~76% of the total annotated protein-coding genes), where they are expressed and in which quantities. Moreover, a widespread yet tissue- and cell type-specific phosphorylation pattern is clearly represented in our data (>50,000 sites). We further leverage our analysis by integrating the phenotypic response of a the murine PDAC cell lines panel to cancer drugs and ionizing radiation, to shed light on the molecular mechanisms underlying drug action and radioresistance. This large and unique atlas is made available to the scientific community also via ProteomicsDB (https://www.proteomicsDB.org) and the interactive web application PACiFIC (http://pacific.proteomics.wzw.tum.de).
HostingRepository	PRIDE
AnnounceDate	2022-04-01
AnnouncementXML	Submission_2022-04-01_11:51:23.345.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Piero Giansanti
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF; Orbitrap Exploris 480; Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-15 13:29:44	ID requested
⏵ 1	2022-04-01 11:51:23	announced

Dataset with its publication pending

submitter keyword: mouse, mus musculus, proteome, phosphoproteome, PDAC, pancreatic cancer, drug sensitivity, radiation sensitivity

Bernhard Kuster
contact affiliation	Chair of Proteomics and Bioanalytics, Technical University of Munich
contact email	kuster@tum.de
lab head
Piero Giansanti
contact affiliation	Technical University of Munich
contact email	piero.giansanti@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD030983

PRIDE project URI

• PRIDE
  1. PXD030983
     1. Label: PRIDE project
     2. Name: Mass spectrometry-based draft of the mouse proteome