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PXD030785-1

PXD030785 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProtective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
DescriptionThe antiviral immune response to SARS-CoV-2 infection can limit viral spread and prevent development of pneumonic COVID-19. However, the protective immunological response associated with successful viral containment in the upper airways remain unclear. Here, we combine a multiomics approach with longitudinal sampling to reveal temporally resolved protective immune signatures in non-pneumonic and ambulatory SARS-CoV-2 infected patients and associate specific immune trajectories with upper airway viral containment. We see a distinct systemic rather than local immune state associated with viral containment, characterized by interferon stimulated gene (ISG) upregulation across circulating immune cell subsets in non-pneumonic SARS-CoV2 infection. We report reduced cytotoxic potential of Natural Killer (NK) and T cells, and an immune-modulatory monocyte phenotype with protective immunity in COVID-19. Together, we show protective immune trajectories in SARS-CoV2 infection, which have important implications for patient prognosis and the development of immunomodulatory therapies.
HostingRepositoryPRIDE
AnnounceDate2022-01-26
AnnouncementXMLSubmission_2022-01-26_08:42:49.776.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterOliver Popp
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-01-06 01:58:57ID requested
12022-01-26 08:42:50announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human, Plasma, Proteomics, SARS-CoV-2, COVID-19
Contact List
Philipp Mertins
contact affiliationProteomics Platform Max Delbrück Center for Molecular Medicine in the Helmholtz Association Robert-Rössle-Straße 10 13125 Berlin, Germany
contact emailphilipp.mertins@mdc-berlin.de
lab head
Oliver Popp
contact affiliationMDC Berlin
contact emailoliver.popp@mdc-berlin.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
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