PXD030615 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Interfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins |
Description | Melanoma is the most serious and deadly form of skin cancer and with progression to advanced melanoma, the intrinsically disordered protein α-synuclein is upregulated to high levels; and while toxic to dopaminergic neurons in Parkinson’s disease, it is highly beneficial for primary and metastatic melanoma cells. To gain detailed insights, both at the level of the proteome and the transcriptome, into this exact opposite role of α-synuclein in advanced melanoma, we performed proteome and transcriptome studies of high-level α-synuclein-expressing primary and metastatic human melanoma cell lines and metastatic human melanoma xenografts treated with the small-molecule diphenyl-pyrazole compound anle138b, which binds to and interferes with the oligomeric structure of α-synuclein. Our data demonstrate that interfering with oligomerized α-synuclein in these melanoma cells and tumor xenografts leads to a substantial upregulation of major histocompatibility complex (MHC) proteins, which are important for enhancing anti-melanoma immune responses. |
HostingRepository | PRIDE |
AnnounceDate | 2024-07-04 |
AnnouncementXML | Submission_2024-07-03_16:38:57.078.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ivan Silbern |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue |
Instrument | Orbitrap Fusion Lumos; Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-12-23 00:22:51 | ID requested | |
⏵ 1 | 2024-07-03 16:38:57 | announced | |
2 | 2024-10-22 06:48:49 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: MHC, xenograft,melanoma, anle138b |
Contact List
Prof. Dr. Henning Urlaub |
contact affiliation | Institute for Biophysical Chemistry, Bioanalytical Mass Spectrometry group, Am Fassberg 11, 37077, Goettingen |
contact email | henning.urlaub@mpibpc.mpg.de |
lab head | |
Ivan Silbern |
contact affiliation | MPI Biophysical Chemistry |
contact email | ivansilbern@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD030615
- Label: PRIDE project
- Name: Interfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins