PXD030390-1

PXD030390 is an original dataset announced via ProteomeXchange.

Title	Proteomic Signature for Detection of High Grade Ovarian Cancer in germline BRCA mutation carriers
Description	There are currently no screening methods for high grade ovarian cancer (HGOC) that guarantee effective early detection for high risk women such as germline BRCA mutation carriers. Therefore, the standard-of-care remains risk reducing salpingo-oophorectomy (RRSO) around age 40. Proximal liquid biopsy has been shown to be a promising source of biomarkers, but sensitivity has not yet qualified for clinical implementation. We report the discriminant performance of a novel proteomic classifier for detection of HGOC in high-risk population, and the safety and feasibility of simplified utero-tubal lavage (UtL) as a method for sampling proximal liquid biopsy.The training set included 93 women with high-risk for HGOC (BRCA1 and BRCA2 mutation carriers), including: 16 HGOC patients and 77 asymptomatic women, who donated UtL liquid biopsies, in 3 Israeli medical centers (Biomarkers for Early Detection of Ovarian Cancer Using Uterine Lavage (BEDOCA); ClinicalTrials.gov Identifier: NCT03150121). The proteome of the microvesicle fraction of the samples was profiled by mass spectrometry and a classifier was developed using logistic regression. An independent cohort of 104 BRCA mutation carriers was used as validation. Safety information was collected for all women who opted to UtL in a clinic setting.
HostingRepository	PRIDE
AnnounceDate	2022-09-13
AnnouncementXML	Submission_2022-09-13_05:15:20.832.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamar Geiger
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-14 07:59:51	ID requested
⏵ 1	2022-09-13 05:15:21	announced

Dataset with its publication pending

submitter keyword: Ovarian cancer, biomarkers, liquid biopsies, BRCA, uterine lavage

Tami Geiger
contact affiliation	Weizmann Institute of Science
contact email	tami.geiger@weizmann.ac.il
lab head
Tamar Geiger
contact affiliation	Weizmann Institute of Science
contact email	geiger@tauex.tau.ac.il
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD030390
     1. Label: PRIDE project
     2. Name: Proteomic Signature for Detection of High Grade Ovarian Cancer in germline BRCA mutation carriers