PXD030254-1

PXD030254 is an original dataset announced via ProteomeXchange.

Title	Quantitative phosphoproteomics study for assessing rodent thyroid toxicity
Description	Here, we aimed to apply a TMT based quantitative phosphoproteomics approach to investigate rodent thyroid toxicity. For this purpose, male Wistar rats have been exposed to a direct (6-propyl-2-thiouracil, PTU) and an indirect (phenytoin) thyroid toxicant, respectively. Thereby, two doses (low:5ppm for PTU and 300ppm for phenytoin , high: 50ppm for PTU and 2400ppm for phenytoin) and three exposure time phase (short: 2 weeks, long:4 weeks, and long+recovery: 4weeks+2weeks) were investigated, allowing insights into the modes of action during thyroid toxicity. Phosphoproteomics were applied to liver.
HostingRepository	PRIDE
AnnounceDate	2024-10-25
AnnouncementXML	Submission_2024-10-25_05:56:37.149.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD030254
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Zhipeng Wang
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-08 12:28:14	ID requested
⏵ 1	2024-10-25 05:56:37	announced

10.1007/S00204-024-03876-2;

10.6019/PXD030254;

submitter keyword: Phosphoproteomics, Liver, TMT,Thyroid toxicity, PTU, Phenytoin

Kristin Schubert
contact affiliation	Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research GmbH – UFZ, 04318 Leipzig, Germany
contact email	kristin.schubert@ufz.de
lab head
Zhipeng Wang
contact affiliation	Helmholtz Centre for Environmental Research
contact email	zhipeng.wang@ufz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD030254

PRIDE project URI

• PRIDE
  1. PXD030254
     1. Label: PRIDE project
     2. Name: Quantitative phosphoproteomics study for assessing rodent thyroid toxicity