PXD030159 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Cubilin is a Novel Target Antigen in Anti-Brush Border Antibody Disease |
Description | Autoimmune diseases that affect the kidney proximal tubule (PT) cause proteinuria and are implicated in the pathogenesis of kidney failure. Previous evidence demonstrated that circulating anti-brush border antibodies (ABBA) target megalin (LRP2) but whether other components of the PT drive autoimmunity was unknown. Here we investigate a patient with LRP2-negative ABBA disease, and applied immunoprecipitation, mass spectrometry, and confocal imaging to identify cubilin as a novel antigen associated with the autoimmune disorder. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:44:34.889.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Aaron Storey |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-12-03 04:43:48 | ID requested | |
1 | 2023-04-06 11:48:05 | announced | |
⏵ 2 | 2023-11-14 08:44:36 | announced | 2023-11-14: Updated project metadata. |
Publication List
Morelle J, Caza T, Debiec H, Aydin S, Storey A, Ronco P, Larsen C, Cubilin and amnionless protein are novel target antigens in anti-brush border antibody disease. Kidney Int, 101(5):1063-1068(2022) [pubmed] |
Keyword List
submitter keyword: Human, DIA, Kidney, LC-MS |
Contact List
Christopher Larsen |
contact affiliation | Arkana Laboratories, Little Rock, AR |
contact email | chris.larsen@arkanalabs.com |
lab head | |
Aaron Storey |
contact affiliation | University of Arkansas for Medical Sciences |
contact email | ajstorey@uams.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD030159
- Label: PRIDE project
- Name: Cubilin is a Novel Target Antigen in Anti-Brush Border Antibody Disease