PXD030129-1

PXD030129 is an original dataset announced via ProteomeXchange.

Title	Mitochondrial antiviral-signalling protein is a client of the BAG6 QC complex
Description	The heterotrimeric BAG6 complex coordinates the direct handover of newly synthesised tail-anchored (TA) membrane proteins from an SGTA-bound preloading complex to the endoplasmic reticulum (ER) delivery component TRC40. In contrast, defective precursors, including aberrant TA proteins, form a stable complex with this cytosolic protein quality control factor, enabling such clients to be either productively re-routed or selectively degraded. We identify the mitochondrial TA protein MAVS (mitochondrial antiviral-signalling protein) as an endogenous client of both SGTA and the BAG6 complex. Our data suggest that the BAG6 complex binds to a cytosolic pool of MAVS before its misinsertion into the ER membrane, from where it can subsequently be removed via ATP13A1-mediated dislocation. This BAG6-associated fraction of MAVS is dynamic and responds to the activation of an innate immune response, suggesting that BAG6 may modulate the pool of MAVS that is available for coordinating the cellular response to viral infection.
HostingRepository	PRIDE
AnnounceDate	2022-04-26
AnnouncementXML	Submission_2022-04-26_02:28:27.359.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Craig Lawless
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-02 04:54:34	ID requested
⏵ 1	2022-04-26 02:28:27	announced

Dataset with its publication pending

submitter keyword: BioID, MAVS, BioID2, BAG6

Stephen High
contact affiliation	Professor of Biochemistry School of Biological Sciences Faculty of Biology, Medicine and Health. University of Manchester The Michael Smith Building Oxford Road Manchester. M13 9PT.
contact email	stephen.high@manchester.ac.uk
lab head
Craig Lawless
contact affiliation	University of Manchester
contact email	craig.lawless@manchester.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD030129

PRIDE project URI

• PRIDE
  1. PXD030129
     1. Label: PRIDE project
     2. Name: Mitochondrial antiviral-signalling protein is a client of the BAG6 QC complex