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PXD030129 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMitochondrial antiviral-signalling protein is a client of the BAG6 QC complex
DescriptionThe heterotrimeric BAG6 complex coordinates the direct handover of newly synthesised tail-anchored (TA) membrane proteins from an SGTA-bound preloading complex to the endoplasmic reticulum (ER) delivery component TRC40. In contrast, defective precursors, including aberrant TA proteins, form a stable complex with this cytosolic protein quality control factor, enabling such clients to be either productively re-routed or selectively degraded. We identify the mitochondrial TA protein MAVS (mitochondrial antiviral-signalling protein) as an endogenous client of both SGTA and the BAG6 complex. Our data suggest that the BAG6 complex binds to a cytosolic pool of MAVS before its misinsertion into the ER membrane, from where it can subsequently be removed via ATP13A1-mediated dislocation. This BAG6-associated fraction of MAVS is dynamic and responds to the activation of an innate immune response, suggesting that BAG6 may modulate the pool of MAVS that is available for coordinating the cellular response to viral infection.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterCraig Lawless
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-12-02 04:54:34ID requested
12022-04-26 02:28:27announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: BioID, MAVS, BioID2, BAG6
Contact List
Stephen High
contact affiliationProfessor of Biochemistry School of Biological Sciences Faculty of Biology, Medicine and Health. University of Manchester The Michael Smith Building Oxford Road Manchester. M13 9PT.
contact emailstephen.high@manchester.ac.uk
lab head
Craig Lawless
contact affiliationUniversity of Manchester
contact emailcraig.lawless@manchester.ac.uk
dataset submitter
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Dataset FTP location
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