PXD030034-1

PXD030034 is an original dataset announced via ProteomeXchange.

Title	The molecular landscape of homologous recombination deficient, end-stage, high grade serous ovarian cancer
Description	High grade serous cancer (HGSC) is frequently characterizsed by homologous recombination (HR) DNA repair deficiency, and while most such tumours are sensitive to initial treatment, acquired resistance is common. We undertook a multi-omics approach to interrogating mechanisms of resistance, using multiple autopsy samples collected from 15 women with HR-deficient HGSC. We observed frequent reversion mutations, resistance mechanisms restoring HR by other means, a high frequency of whole-genome duplication (WGD) suggestive of an evolutionary advantage, and global changes in immune composition with evidence of immune escape. Collectively these findings have implications for therapeutic intervention for HR-deficient HGSC.
HostingRepository	PRIDE
AnnounceDate	2023-02-28
AnnouncementXML	Submission_2023-02-28_02:18:30.145.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	ThomasConrads
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-29 02:11:28	ID requested
⏵ 1	2023-02-28 02:18:30	announced
2	2023-11-14 08:53:41	announced	2023-11-14: Updated project metadata.

submitter keyword: Ovarian cancer

High grade serous cancer

Multi-omics

Acquired resistance

Dr. Elizabeth LChristie
contact affiliation	Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Centre, The University of Melbourne, Victoria 3000, Australia
contact email	liz.christie@petermac.org
lab head
ThomasConrads
contact affiliation	Inova Health System
contact email	conrads@whirc.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/02/PXD030034

PRIDE project URI

• PRIDE
  1. PXD030034
     1. Label: PRIDE project
     2. Name: The molecular landscape of homologous recombination deficient, end-stage, high grade serous ovarian cancer