PXD030028-1

PXD030028 is an original dataset announced via ProteomeXchange.

Title	Rewiring the metabolic network to increase docosahexaenoic acid productivity in Crypthecodinium cohnii by fermentation supernatant-based adaptive laboratory evolution
Description	To overcome the inhibition caused by the fermentation supernatant in the late fermentation stage of docosahexaenoic acid (DHA)-producing Crypthecodinium cohnii, fermentation supernatant-based adaptive laboratory evolution (FS-ALE) was conducted. The cell growth and DHA productivity of the evolved strain (FS280) obtained after 280 adaptive cycles corresponding to 840 days of evolution were increased by 161.87% and 311.23%, respectively, at 72 h under stress conditions and increased by 19.87% and 51.79% without any stress compared with the starting strain, demonstrating the effectiveness of FS-ALE.
HostingRepository	iProX
AnnounceDate	2021-11-27
AnnouncementXML	Submission_2021-11-28_22:13:04.991.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lei Chen
SpeciesList	scientific name: Crypthecodinium cohnii; NCBI TaxID: 2866;
ModificationList	No PTMs are included in the dataset
Instrument	Thermo RAW format

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-28 22:12:45	ID requested
⏵ 1	2021-11-28 22:13:05	announced
2	2022-10-12 19:44:29	announced	2022-10-13: Update publication information.

Dataset with its publication pending

submitter keyword: Crypthecodinium cohnii, fermentation supernatant tolerance, adaptive laboratory evolution, docosahexaenoic acid

Weiwen Zhang
contact affiliation	Tianjin University, China
contact email	wwzhang8@tju.edu.cn
lab head
Lei Chen
contact affiliation	Tianjin University, China
contact email	lchen@tju.edu.cn
dataset submitter

iProX dataset URI